RNA Details
Disease Name
idiopathic pulmonary fibrosis
Tissue
lung
RNA Symbol
NOX4
RNA ID
RNA Type
mRNA
Alteration Pattern
histone acetylation
Species
homo sapiens
Detection Methods
qRT-PCR; Immunoblot; Chromatin immunoprecipitation assay etc.
Target
NA
Pathway
NA
PubMed ID
Title
Epigenetic mechanisms regulate NADPH oxidase-4 expression in cellular senescence
Year
2015
Function
"In replicative senescent fibroblasts, the Nox4 gene is enriched with the activation histone mark, H4K16Ac, and inversely associated with the repressive histone mark, H4K20Me3, supporting an active transcriptional chromatin conformation. Silencing of the histone acetyltransferase Mof, which specifically acetylates H4K16, down-regulates Nox4 gene/protein expression."